glutathione astrocyte recycling Frontiers GSH synthesis in CNS. GSH

Exosomes secreted by intestinal epithelial cells (IECs) contain specific miRNAs post-AIEC infection, which transfer to recipient IECs, suppressing autophagy-mediated intracellular AIEC clearance [52]

The combined treatments of Glutathione and Vitamin C are generally well-tolerated

Kaplowitz et al

It appears that NRF2 induces the p62 protein, which in turn increases Nrf2 activity and, along with reduced Keap1 levels, may stimulate autophagy, consistent with the activation of the LC3A/B protein

This combination of increased consumption and decreased production creates the perfect environment for NAD+ depletion in aging bodies